RELN
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IMP]
- associative learning [IDA]
- axon guidance [IMP]
- brain development [IMP, ISO]
- cell migration [IMP]
- cell morphogenesis involved in differentiation [IMP]
- central nervous system development [IMP]
- cerebral cortex development [IMP]
- cerebral cortex tangential migration [IMP]
- dendrite development [IGI, IMP]
- dentate gyrus development [ISO]
- forebrain development [IMP]
- glial cell differentiation [IMP]
- hippocampus development [IDA]
- lateral motor column neuron migration [IMP]
- layer formation in cerebral cortex [IMP]
- locomotory behavior [IMP, ISO]
- long-term memory [IDA]
- neuron migration [IGI, IMP, ISO]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of TOR signaling [IDA]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- positive regulation of dendritic spine morphogenesis [IDA, IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP]
- positive regulation of lateral motor column neuron migration [IMP]
- positive regulation of long-term synaptic potentiation [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of small GTPase mediated signal transduction [IDA]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- postsynaptic density assembly [IC]
- postsynaptic density protein 95 clustering [IMP]
- protein localization to synapse [IMP]
- receptor localization to synapse [IMP]
- reelin-mediated signaling pathway [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of behavior [IMP]
- regulation of gene expression [IMP]
- regulation of synaptic transmission [IMP]
- response to pain [IMP]
- spinal cord patterning [IMP]
- thyroid hormone metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APP
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.
The processing of amyloid precursor protein (APP) to Abeta is an important event in the pathogenesis of Alzheimer's disease, but the physiological function of APP is not well understood. Our previous work has shown that APP processing and Abeta production are regulated by the extracellular matrix protein Reelin. In the present study, we examined whether Reelin interacts with APP, and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RELN APP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| APP RELN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID