HERC5
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of defense response to virus [IDA]
Gene Ontology Molecular Function
CDKN1A
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IDA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- G1/S transition of mitotic cell cycle [IDA, TAS]
- G2/M transition of mitotic cell cycle [IMP]
- Ras protein signal transduction [IEP]
- cell cycle arrest [IDA, IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to extracellular stimulus [IMP]
- cellular response to ionizing radiation [IMP]
- cellular senescence [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of G1/S transition of mitotic cell cycle [IGI]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of phosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of protein kinase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [IMP]
- protein phosphorylation [IDA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- stress-induced premature senescence [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.
Cyclin E-Cdk2 is an evolutionary conserved cyclin-dependent kinase (CDK) complex that drives the G1 to S phase transition of the cell cycle. A novel cDNA encoding a HECT family protein also containing RCC1-like repeats was isolated by a yeast two-hybrid screening using both cyclin E and its inhibitor p21. The protein product of this cDNA, Ceb1, interacts with various cyclin ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID