BAIT
SLX4IP
C20orf94, bA204H22.1, bA254M13.1, dJ1099D15.3, RP5-1099D15.1
SLX4 interacting protein
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
MAP6
MTAP6, N-STOP, STOP
microtubule-associated protein 6
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that are repaired via a complex process requiring the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia, which is characterized by bone marrow failure, developmental abnormalities, and a high incidence of malignancies. SLX4, also known as FANCP, acts as a scaffold protein and coordinates multiple endonucleases ... [more]
Nucleic Acids Res. Dec. 04, 2018; 47(19);10181-10201 [Pubmed: 31495888]
Throughput
- High Throughput
Curated By
- BioGRID