ZFP36
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA catabolic process [IDA]
- mRNA metabolic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of translation involved in gene silencing by miRNA [ISS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IDA]
- regulation of tumor necrosis factor production [IDA]
- response to starvation [IDA]
Gene Ontology Molecular Function
ATG16L1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.
Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-inducing compounds, the ubiquitin ligase FBXW7/CDC4 (F-box and WD repeat domain containing 7) decreased ZFP36 protein ... [more]
Throughput
- Low Throughput
Additional Notes
- interaction of RNA corresponding to hit gene, ATG16L1, with protein corresponding to bait gene, ZFP36, detected by RIP (RNA immunoprecipation) followed by real time PCR (polymerase chain reaction)
- interaction of RNA corresponding to hit gene, ATG16L1, with protein corresponding to bait gene, ZFP36, detected by real time PCR (polymerase chain reaction) following RIP (RNA immunoprecipitation)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATG16L1 ZFP36 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 2768082 |
Curated By
- BioGRID