Publication

Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation.

Arevalo JC, Pereira DB, Yano H, Teng KK, Chao MV

Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, activate Trk receptor tyrosine kinases through receptor dimerization at the cell surface followed by autophosphorylation and recruitment of intracellular signaling molecules. The intracellular pathways used by neurotrophins share many common protein substrates that are used by other receptor tyrosine kinases (RTK), such as Shc, Grb2, FRS2, and phospholipase C-gamma. Here ... [more]

Throughput

• Low Throughput

Additional Notes

• Source of bait is unclear

Curated By

• BioGRID