TRIO
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine phosphatase signaling pathway [TAS]
Gene Ontology Molecular Function
DISC1
Gene Ontology Biological Process
- TOR signaling [IMP]
- canonical Wnt signaling pathway [IMP]
- cell proliferation in forebrain [IMP]
- cellular protein localization [IDA]
- cerebral cortex radially oriented cell migration [IMP]
- cilium assembly [ISO]
- microtubule cytoskeleton organization [ISO]
- mitochondrial calcium ion homeostasis [IMP]
- nervous system development [ISO]
- neuron migration [IMP, ISO]
- positive regulation of Wnt signaling pathway [IMP, ISO]
- positive regulation of axon extension [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of neuroblast proliferation [IMP, ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- protein localization [IDA]
- pyramidal neuron migration [ISO]
- regulation of dendritic spine development [ISO]
- regulation of neuron projection development [IMP, ISO]
- regulation of synapse maturation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling.
Defects in neuronal connectivity of the brain are well documented among schizophrenia patients. Although the schizophrenia susceptibility gene Disrupted-in-Schizophrenia 1 (DISC1) has been implicated in various neurodevelopmental processes, its role in regulating axonal connections remains elusive. Here, a heterologous DISC1 transgenic system in the relatively simple and well-characterized Caenorhabditis elegans motor neurons has been established to investigate whether DISC1 regulates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID