PTPRF
Gene Ontology Biological Process
- cell migration [ISO, ISS]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of cell projection organization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytokine-mediated signaling pathway [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of neurotrophin TRK receptor signaling pathway [IMP]
- negative regulation of receptor binding [ISO, ISS]
- nervous system development [IDA]
- peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of dendrite morphogenesis [IMP]
- positive regulation of neuron apoptotic process [IMP]
- protein dephosphorylation [IDA]
- regulation of axon regeneration [ISO]
- regulation of neuron projection development [ISO]
- regulation of synapse structure or activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDH2
Gene Ontology Biological Process
- blood vessel morphogenesis [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IMP, ISO]
- cell adhesion [ISO]
- cell migration [ISO]
- cell-cell adhesion mediated by cadherin [ISO, ISS]
- glial cell differentiation [ISO, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- neuronal stem cell maintenance [ISO, ISS]
- positive regulation of MAPK cascade [ISO]
- protein heterooligomerization [IPI]
- regulation of Rho protein signal transduction [IMP]
- regulation of axonogenesis [IMP]
- regulation of myelination [IMP]
- regulation of protein localization [IMP]
- single organismal cell-cell adhesion [IDA]
- striated muscle cell differentiation [ISO]
- synapse assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- adherens junction [ISO]
- apical plasma membrane [ISO]
- catenin complex [ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [ISO]
- membrane [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- synapse [IDA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses.
Leukocyte common antigen-related (LAR) family receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in axon guidance. We report that LAR-RPTP is concentrated in mature synapses in cultured rat hippocampal neurons, and is important for the development and maintenance of excitatory synapses in hippocampal neurons. RNA interference (RNAi) knockdown of LAR or dominant-negative disruption of LAR function ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID