BAIT
ORF50
HHV8GK18_gp52
transactivator
GO Process (0)
GO Function (0)
GO Component (0)
Human Herpesvirus 8
PREY
EIF2S1
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA.
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcriptional activator and RTA expression is sufficient to activate complete lytic replication, RTA ... [more]
PLoS Pathog. Dec. 01, 2018; 15(11);e1008160 [Pubmed: 31751430]
Throughput
- High Throughput
Curated By
- BioGRID