BAIT

NSP2AB

nsp2, sars1ab, orf1ab, SARS-CoV nsp2ab, SARS-CoV nsp2, SARS-CoV sars1ab, orf1ab-nsp2, orf1ab-nsp2ab, pp1ab, p65 homolog, R1AB_CVHSA, PRO_0000037310, SARS-CoV-1ab-nsp2ab

Non-structural protein 2; nsp2; p65 homolog

COVID-19 Coronavirus Project

GO Process (0)

GO Function (0)

GO Component (0)

Entrez Gene RefSeq UniprotKB

Severe acute respiratory syndrome coronavirus

PREY

GIGYF2

GYF2, PARK11, PERQ2, PERQ3, TNRC15

GRB10 interacting GYF protein 2

GO Process (1)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

negative regulation of translation [IMP]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

membrane [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.

Davies JP, Almasy KM, McDonald EF, Plate L

Human coronaviruses (hCoVs) have become a threat to global health and society, as evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent COVID-19 pandemic caused by SARS-CoV-2. Despite a high sequence similarity between SARS-CoV-1 and -2, each strain has a distinctive virulence. A better understanding of the basic molecular mechanisms mediating changes in virulence is ... [more]

ACS Infect Dis Dec. 11, 2019; 6(12);3174-3189 [Pubmed: 33263384]

Throughput

High Throughput

Additional Notes

High confidence interactors

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NSP2AB GIGYF2	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Cornillez-Ty CT (2009)	Low	-	BioGRID	-
NSP2AB GIGYF2	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Gordon DE (2020)	High	0.8738	BioGRID	2875897

Curated By

BioGRID

Interaction Summary