BAIT
PLAT
T-PA, TPA
plasminogen activator, tissue
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLAU
ATF, BDPLT5, QPD, UPA, URK, u-PA, RP11-417O11.1
plasminogen activator, urokinase
GO Process (9)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- chemotaxis [TAS]
- fibrinolysis [TAS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of receptor activity [IDA]
- regulation of smooth muscle cell migration [IDA]
- regulation of smooth muscle cell-matrix adhesion [IDA]
- regulation of wound healing [IC]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA's lysine binding site. An explanation of the poor fibrin affinity of recombinant tPA/uPA chimeric molecules.
Differential scanning calorimetry was used to study the domain structure and intramolecular interactions of tPA/uPA chimeras. A high temperature transition centered near 90 degrees C was observed upon melting of the tPA/uPA chimera (amino acids 1-274 of tPA and 138-411 of uPA) and its variant lacking the finger and epidermal growth factor-like modules (residues 1-3 and 87-274 of tPA and ... [more]
J. Biol. Chem. Apr. 14, 1995; 270(15);8680-5 [Pubmed: 7721771]
Throughput
- Low Throughput
Curated By
- BioGRID