BAIT
NRXN1
Hs.22998, PTHSL2, SCZD17
neurexin 1
GO Process (38)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [IMP]
- angiogenesis [ISS]
- axon guidance [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- extracellular matrix organization [TAS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [IMP]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISS]
- neuromuscular process controlling balance [IMP, ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- neurotransmitter secretion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synapse maturation [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse assembly [ISS]
- synaptic transmission [ISS]
- synaptic vesicle clustering [ISS]
- vocal learning [IMP]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NLGN1
NL1
neuroligin 1
GO Process (36)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cytoskeletal matrix organization at active zone [ISS]
- establishment of protein localization [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- metabolic process [IBA]
- nervous system development [ISS]
- neurexin clustering [ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular signal transduction [ISS]
- positive regulation of ruffle assembly [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- positive regulation of synaptic vesicle endocytosis [ISS]
- positive regulation of synaptic vesicle exocytosis [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein homooligomerization [ISS]
- protein localization to synapse [ISS]
- protein targeting [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of neuron differentiation [ISS]
- regulation of synaptic transmission [IBA]
- synapse assembly [IBA, ISS]
- synaptic vesicle clustering [ISS]
- synaptic vesicle targeting [ISS]
- terminal button organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neurexin mediates the assembly of presynaptic terminals.
Neurexins are a large family of proteins that act as neuronal cell-surface receptors. The function and localization of the various neurexins, however, have not yet been clarified. Beta-neurexins are candidate receptors for neuroligin-1, a postsynaptic membrane protein that can trigger synapse formation at axon contacts. Here we report that neurexins are concentrated at synapses and that purified neuroligin is sufficient ... [more]
Nat. Neurosci. Jul. 01, 2003; 6(7);708-16 [Pubmed: 12796785]
Throughput
- Low Throughput
Additional Notes
- Species of bait and hit is not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRXN1 NLGN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| NRXN1 NLGN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID