RYR2
Gene Ontology Biological Process
- Purkinje myocyte to ventricular cardiac muscle cell signaling [ISS]
- calcium ion transport [IDA]
- calcium ion transport into cytosol [IDA]
- calcium-mediated signaling [ISS]
- calcium-mediated signaling using intracellular calcium source [IDA]
- cardiac muscle contraction [IMP]
- cardiac muscle hypertrophy [ISS]
- cell communication by electrical coupling involved in cardiac conduction [IC]
- cellular calcium ion homeostasis [ISS]
- cellular response to caffeine [IDA, ISS]
- cellular response to epinephrine stimulus [TAS]
- cytosolic calcium ion homeostasis [ISS]
- detection of calcium ion [IDA]
- embryonic heart tube morphogenesis [ISS]
- establishment of protein localization to endoplasmic reticulum [IDA]
- ion transmembrane transport [TAS]
- left ventricular cardiac muscle tissue morphogenesis [ISS]
- positive regulation of calcium-transporting ATPase activity [IDA]
- positive regulation of heart rate [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [ISS]
- positive regulation of sequestering of calcium ion [IDA]
- positive regulation of the force of heart contraction [IMP]
- regulation of cardiac muscle contraction [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC, ISS]
- regulation of heart rate [IMP]
- release of sequestered calcium ion into cytosol [IDA, ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP, ISS]
- response to caffeine [IDA]
- response to hypoxia [ISS]
- response to muscle stretch [IMP]
- response to redox state [IDA]
- sarcoplasmic reticulum calcium ion transport [TAS]
- transmembrane transport [TAS]
- type B pancreatic cell apoptotic process [IMP]
- ventricular cardiac muscle cell action potential [ISS]
Gene Ontology Molecular Function- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
- calcium channel activity [ISS]
- calcium-induced calcium release activity [IDA]
- calcium-release channel activity [IDA]
- calmodulin binding [IMP, IPI, ISS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- intracellular ligand-gated calcium channel activity [ISS]
- ion channel binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IDA]
- protein kinase A regulatory subunit binding [IDA]
- ryanodine-sensitive calcium-release channel activity [IDA]
- suramin binding [IMP]
Gene Ontology Cellular Component
SRI
Gene Ontology Biological Process
- action potential [TAS]
- intracellular sequestering of iron ion [TAS]
- muscle organ development [TAS]
- negative regulation of heart rate [IMP]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- proteolysis [IBA]
- regulation of calcium ion transport [IMP]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of cell communication by electrical coupling [TAS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IMP]
- regulation of heart contraction [TAS]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of relaxation of muscle [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [TAS]
- regulation of striated muscle contraction [TAS]
- signal transduction [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of sorcin with the cardiac ryanodine receptor.
Sorcin is a 22-kDa calcium-binding protein initially identified in multidrug-resistant cells; however, its patterns of expression and function in normal tissues are unknown. Here we demonstrate that sorcin is widely distributed in rodent tissues, including the heart, where it was localized by immunoelectron microscopy to the sarcoplasmic reticulum. A > 500-kDa protein band immunoprecipitated from cardiac myocytes by sorcin antiserum ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRI RYR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SRI RYR2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID