BAIT
DPM1
CDGIE, MPDS, RP5-914P20.2
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- C-terminal protein lipidation [TAS]
- GPI anchor biosynthetic process [IDA]
- cellular protein metabolic process [TAS]
- dolichol metabolic process [IDA]
- dolichol-linked oligosaccharide biosynthetic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein O-linked mannosylation [IDA]
- protein mannosylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DPM2
CDG1U, RP11-203J24.2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
GO Process (10)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- C-terminal protein lipidation [TAS]
- GPI anchor biosynthetic process [IDA]
- cellular protein metabolic process [TAS]
- dolichol metabolic process [IBA]
- dolichol-linked oligosaccharide biosynthetic process [TAS]
- post-translational protein modification [TAS]
- preassembly of GPI anchor in ER membrane [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein O-linked mannosylation [TAS]
- regulation of protein stability [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
Dolichol-phosphate-mannose (DPM) synthase generates mannosyl donors for glycosylphosphatidylinositols, N-glycan and protein O- and C-mannosylation. In Saccharomyces cerevisiae, this enzyme is encoded by DPM1. We reported previously that mammalian DPM synthase contains catalytic DPM1 and regulatory DPM2 subunits, and that DPM1 requires DPM2 for its stable expression in the endoplasmic reticulum. Here we report that human DPM synthase consists of three ... [more]
EMBO J. Jun. 01, 2000; 19(11);2475-82 [Pubmed: 10835346]
Throughput
- Low Throughput
Curated By
- BioGRID