CDC42EP5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEPT2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISO, TAS]
- actomyosin contractile ring [NAS]
- cell cortex [TAS]
- cell projection [IDA]
- cell surface [IDA]
- ciliary membrane [IDA]
- ciliary transition zone [IDA]
- cytoplasm [ISO]
- exocyst [ISO]
- extracellular vesicular exosome [ISO]
- microtubule cytoskeleton [TAS]
- midbody [TAS]
- myelin sheath [IDA]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- spindle microtubule [TAS]
- synapse [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Borg proteins control septin organization and are negatively regulated by Cdc42.
The Cdc42 GTPase binds to numerous effector proteins that control cell polarity, cytoskeletal remodelling and vesicle transport. In many cases the signalling pathways downstream of these effectors are not known. Here we show that the Cdc42 effectors Borg1 to Borg3 bind to septin GTPases. Endogenous septin Cdc10 and Borg3 proteins can be immunoprecipitated together by an anti-Borg3 antibody. The ectopic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID