Syntrophins are modular adapter proteins that link ion channels and signaling proteins to dystrophin and its homologues. A yeast two-hybrid screen of a human brain cDNA library using the PDZ domain of gamma 1- syntrophin, a recently identified brain-specific isoform, yielded overlapping clones encoding the C terminus of diacylglycerol kinase-zeta (DGK-zeta), an enzyme that converts diacylglycerol into phosphatidic acid. In ... [more]

J. Biol. Chem. Jul. 13, 2001; 276(28);26526-33 [Pubmed: 11352924]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

DGKZ

Gene Ontology Biological Process

Gene Ontology Molecular Function

diacylglycerol kinase activity [IDA]lipid kinase activity [IDA]protein C-terminus binding [IDA]protein binding [IPI]

Gene Ontology Cellular Component

SNTA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATPase binding [IPI]ion channel binding [IPI]nitric-oxide synthase binding [IPI]protein binding [IPI]sodium channel regulator activity [IMP]

Gene Ontology Cellular Component

Reconstituted Complex

Publication

Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.

Throughput

Curated By

diacylglycerol kinase activity [IDA]
lipid kinase activity [IDA]
protein C-terminus binding [IDA]
protein binding [IPI]

ATPase binding [IPI]
ion channel binding [IPI]
nitric-oxide synthase binding [IPI]
protein binding [IPI]
sodium channel regulator activity [IMP]