DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS, TAS]
- axon guidance [TAS]
- dendritic spine morphogenesis [ISS]
- establishment of protein localization [IDA]
- learning [TAS]
- negative regulation of receptor internalization [ISS]
- nervous system development [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synaptic transmission [ISS]
- protein complex assembly [IDA]
- protein localization to synapse [IDA]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
- synaptic vesicle maturation [ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISS]
- cell junction [ISS]
- cortical cytoskeleton [IDA]
- cytoplasm [ISS]
- dendrite cytoplasm [ISS]
- dendritic spine [ISS]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [ISS]
- excitatory synapse [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [ISS]
- ionotropic glutamate receptor complex [ISS]
- juxtaparanode region of axon [ISS]
- neuron projection terminus [ISS]
- neuron spine [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS, TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IDA]
- synapse [IDA]
- synaptic vesicle [ISS]
- voltage-gated potassium channel complex [ISS]
HGS
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms.
Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses. We report that N-terminal alternative splicing of PSD95 generates an isoform, PSD95beta that contains an additional "L27" motif, ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID