CCL3
Gene Ontology Biological Process
- MAPK cascade [IEP, IMP]
- T cell chemotaxis [IDA]
- astrocyte cell migration [ISS]
- behavior [IDA]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell activation [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemotaxis [IDA]
- cytoskeleton organization [IDA]
- eosinophil chemotaxis [IDA]
- eosinophil degranulation [IDA]
- exocytosis [IDA]
- granulocyte chemotaxis [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymphocyte chemotaxis [IDA]
- macrophage chemotaxis [ISS]
- monocyte chemotaxis [IC, IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of bone mineralization [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of osteoclast differentiation [IDA]
- neutrophil chemotaxis [IDA]
- osteoblast differentiation [IEP]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein kinase B signaling [IEP]
- positive regulation of tumor necrosis factor production [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of sensory perception of pain [IDA]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IDA]
- response to toxic substance [IDA]
- signaling [IEP]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
Gene Ontology Cellular Component
CCR5
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- MAPK cascade [IEP]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [IDA]
- cellular defense response [TAS]
- cellular response to lipopolysaccharide [IEP]
- chemokine-mediated signaling pathway [IDA, NAS, TAS]
- chemotaxis [TAS]
- dendritic cell chemotaxis [TAS]
- entry into host cell [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IMP]
- signaling [IEP]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding.
Molecular analysis of CCR5, the cardinal coreceptor for HIV-1 infection, has implicated the N-terminal extracellular domain (N-ter) and regions vicinal to the second extracellular loop (ECL2) in this activity. It was shown that residues in the N-ter are necessary for binding of the physiologic ligands, RANTES (CCL5) and MIP-1 alpha (CCL3). vMIP-II, encoded by the Kaposi's sarcoma-associated herpesvirus, is a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID