CRY1
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- circadian regulation of gene expression [IGI, IMP]
- circadian rhythm [IDA, IMP]
- entrainment of circadian clock by photoperiod [IMP]
- gluconeogenesis [IMP]
- glucose homeostasis [IGI]
- lipid storage [IGI]
- negative regulation of G-protein coupled receptor protein signaling pathway [IMP]
- negative regulation of circadian rhythm [IDA, IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IDA, IGI]
- negative regulation of glucocorticoid secretion [IGI]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, IGI, ISO]
- regulation of DNA damage checkpoint [IDA]
- regulation of circadian rhythm [IMP]
- response to glucagon [IMP]
- response to insulin [IGI]
Gene Ontology Molecular Function- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- histone deacetylase binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin binding [IDA]
- core promoter binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA, ISO]
- histone deacetylase binding [IPI]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin binding [IDA]
Gene Ontology Cellular Component
CSNK1E
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
The serine/threonine protein kinase casein kinase I epsilon (CKIepsilon) is a key regulator of metazoan circadian rhythm. Genetic and biochemical data suggest that CKIepsilon binds to and phosphorylates the PERIOD proteins. However, the PERIOD proteins interact with a variety of circadian regulators, suggesting the possibility that CKIepsilon may interact with and phosphorylate additional clock components as well. We find that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CRY1 CSNK1E | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1459342 |
Curated By
- BioGRID