BAIT
CARM1
Prmt4
coactivator-associated arginine methyltransferase 1
GO Process (18)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- endochondral bone morphogenesis [IMP]
- histone H3-R17 methylation [IDA]
- histone H3-R2 methylation [ISO]
- histone arginine methylation [IDA]
- histone methylation [IDA, ISO]
- intracellular estrogen receptor signaling pathway [IGI]
- intracellular steroid hormone receptor signaling pathway [IDA]
- negative regulation of dendrite development [ISO]
- negative regulation of protein binding [IDA]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IDA]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of fat cell differentiation [IMP]
- protein methylation [IMP]
- regulation of growth plate cartilage chondrocyte proliferation [IMP]
- regulation of intracellular estrogen receptor signaling pathway [IDA]
- regulation of mRNA binding [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to cAMP [ISO]
Gene Ontology Molecular Function- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H3-R17 specific) [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein methyltransferase activity [IDA]
- protein-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IMP]
- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H3-R17 specific) [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein methyltransferase activity [IDA]
- protein-arginine N-methyltransferase activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IMP]
Mus musculus
PREY
FLII
3632430F08Rik, Fliih, RP23-278I21.3
flightless I homolog (Drosophila)
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.
Hormone-activated nuclear receptors (NR) activate transcription by recruiting multiple coactivator complexes to the promoters of target genes. One important coactivator complex includes a p160 coactivator (e.g., GRIP1, SRC-1, or ACTR) that binds directly to activated NR, the histone acetyltransferase p300 or CBP, and the arginine-specific histone methyltransferase CARM1. We previously demonstrated that the coactivator function of CARM1 depends both on ... [more]
Mol. Cell. Biol. Mar. 01, 2004; 24(5);2103-17 [Pubmed: 14966289]
Throughput
- Low Throughput
Curated By
- BioGRID