SSTR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- cell-cell signaling [TAS]
- cellular response to estradiol stimulus [IBA]
- cellular response to glucocorticoid stimulus [IBA]
- digestion [TAS]
- negative regulation of cell proliferation [TAS]
- neuropeptide signaling pathway [IBA]
- response to nutrient [TAS]
- somatostatin signaling pathway [IBA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHANK1
Gene Ontology Biological Process
- adult behavior [IMP]
- associative learning [ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISS]
- determination of affect [IMP]
- long-term memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- neuromuscular process controlling balance [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- protein complex assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse maturation [ISS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- dendrite [NAS]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS]
- postsynaptic membrane [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.
By using the yeast two-hybrid system we identified a novel protein from the human brain interacting with the C terminus of somatostatin receptor subtype 2. This protein termed somatostatin receptor interacting protein is characterized by a novel domain structure, consisting of six N-terminal ankyrin repeats followed by SH3 and PDZ domains, several proline-rich regions, and a C-terminal sterile alpha motif. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHANK1 SSTR2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID