BAIT
BLNK
BASH, Bca, Ly-57, Ly57, Lyw-57, SLP-65
B cell linker
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP4K1
Hpk1, mHPK1
mitogen-activated protein kinase kinase kinase kinase 1
GO Process (9)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- activation of MAPKKK activity [ISO]
- cell proliferation [ISO]
- intracellular signal transduction [IBA, IDA, ISO]
- peptidyl-serine phosphorylation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA, ISO]
- response to stress [IBA, ISO]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.
B cell linker protein (BLNK) is a SLP-76-related adaptor protein essential for signal transduction from the BCR. To identify components of BLNK-associated signaling pathways, we performed a phosphorylation-dependent yeast two-hybrid analysis using BLNK probes. Here we report that the serine/threonine kinase hematopoietic progenitor kinase 1 (HPK1), which is activated upon antigen-receptor stimulation and which has been implicated in the regulation ... [more]
J. Biol. Chem. Nov. 30, 2001; 276(48);45207-16 [Pubmed: 11487585]
Throughput
- Low Throughput
Curated By
- BioGRID