GRID2
Gene Ontology Biological Process
- cellular protein localization [ISS]
- cerebellar granule cell differentiation [ISS]
- glutamate receptor signaling pathway [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA]
- prepulse inhibition [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of neuron apoptotic process [ISS]
- synaptic transmission, glutamatergic [IBA, ISS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPN4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits.
Glutamate receptor (GluR) delta2 is selectively expressed in cerebellar Purkinje cells and plays a crucial role in cerebellum-dependent motor learning. Although GluRdelta2 belongs to an ionotropic GluR family, little is known about its pharmacological features and downstream signaling cascade. To study molecular mechanisms underlying GluRdelta2-dependent motor learning, we employed yeast two-hybrid screening to isolate GluRdelta2-interacting molecules and identified protein-tyrosine phosphatase ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN4 GRID2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID