BAIT
ZIP-7
CELE_Y51H4A.4
Protein ZIP-7
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
TRA-1
CELE_Y47D3A.6
Protein TRA-1
GO Process (14)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- female germ-line sex determination [TAS]
- female somatic sex determination [IMP, TAS]
- gonad development [IGI]
- hermaphrodite genitalia development [IMP]
- inductive cell migration [IMP]
- meiotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- receptor-mediated endocytosis [IMP]
- reproduction [IMP]
- spermatogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Caenorhabditis elegans
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network.
Gene duplication results in two identical paralogs that diverge through mutation, leading to loss or gain of interactions with other biomolecules. Here, we comprehensively characterize such network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks. Remarkably, we find that even highly similar TFs often have different interaction degrees and partners. In addition, we find that ... [more]
Mol. Cell Jul. 11, 2013; 51(1);116-27 [Pubmed: 23791784]
Throughput
- High Throughput
Curated By
- BioGRID