BAIT
CEH-23
CELE_ZK652.5, ZK652.5
ceh-23 encodes a homeodomain protein required for a specific differentiated trait of the thermosensory interneuron AIY; a ceh-23::gfp promoter fusion is expressed in nine pairs of head neurons, including seven amphid sensory neurons, the BAG sensory neurons, AIY interneurons, and the CAN neurons that are in close association with the excretory canal.
Caenorhabditis elegans
PREY
MAB-5
CELE_C08C3.3, lin-21, C08C3.3
mab-5 encodes a homeodomain transcription factor related to the Antennapedia, Ultrabithorax, and abdominal-A family of homeodomain proteins; during postembryonic development, mab-5 is required cell autonomously for specification of posterior cell fates, including hypodermal and neuronal fates, programmed cell deaths, cell proliferation and migration, and fate specification of the male-specific copulatory muscles and sensory rays; in addition, ectopic expression of mab-5 is sufficient to alter cell fates, such as direction of migration or sensory ray identity; in regions of the body where mab-5 expression overlaps with that of lin-39, another C. elegans HOM-C gene, the two genes appear to either compensate for one another's activity or act combinatorially to promote cell fates distinct from those where either gene is expressed alone; a mab-5:lacZ reporter fusion is expressed in cells in the posterior body region from the mid-gastrulation stage of embryogenesis through larval and adult stages; further, antibody staining reveals that MAB-5 expression in the V5 lineage is dynamic, switching on and off several times, while expression in V6 is continuous throughout most of the L1-L3 larval stages; early MAB-5 expression is V6 is dependent upon wild-type activity of pal-1, which encodes the C. elegans Caudal ortholog.
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IGI, IMP]
- localization [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nematode male tail tip morphogenesis [IGI, IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of cell fate specification [IMP]
- regulation of cell migration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network.
Gene duplication results in two identical paralogs that diverge through mutation, leading to loss or gain of interactions with other biomolecules. Here, we comprehensively characterize such network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks. Remarkably, we find that even highly similar TFs often have different interaction degrees and partners. In addition, we find that ... [more]
Mol. Cell Jul. 11, 2013; 51(1);116-27 [Pubmed: 23791784]
Throughput
- High Throughput
Curated By
- BioGRID