BAIT
UNC-37
CELE_W02D3.9, ESG, let-76, W02D3.9
unc-37 encodes a transducin-like WD-repeat protein orthologous to Drosophila Groucho; unc-37 plays an essential role in embryonic and neuronal fate specification; unc-37 genetically interacts with components of the transcriptional Mediator complex.
GO Process (12)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- nematode larval development [IMP]
- oogenesis [IMP]
- pronuclear migration [IMP]
- regulation of axonogenesis [IMP]
- regulation of neurotransmitter levels [IDA]
- regulation of synapse structure or activity [IMP]
- reproduction [IMP]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
FLH-2
CELE_C26E6.2, C26E6.2
FLYWCH zinc finger transcription factor homolog
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Caenorhabditis elegans
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network.
Gene duplication results in two identical paralogs that diverge through mutation, leading to loss or gain of interactions with other biomolecules. Here, we comprehensively characterize such network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks. Remarkably, we find that even highly similar TFs often have different interaction degrees and partners. In addition, we find that ... [more]
Mol. Cell Jul. 11, 2013; 51(1);116-27 [Pubmed: 23791784]
Throughput
- High Throughput
Curated By
- BioGRID