Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins.

Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP

Identification of protein complexes associated with the ERBB2/HER2 receptor may help unravel the mechanisms of its activation and regulation in normal and pathological situations. Interactions between ERBB2/HER2 and Src homology 2 or phosphotyrosine binding domain signaling proteins have been extensively studied. We have identified ERBIN and PICK1 as new binding partners for ERBB2/HER2 that associate with its carboxyl-terminal sequence through ... [more]

J. Biol. Chem. May. 04, 2001; 276(18);15256-63 [Pubmed: 11278603]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ERBB2IP ERBB2IP	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Jaulin-Bastard F (2001)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

ERBB2IP

Gene Ontology Biological Process

Gene Ontology Molecular Function

ErbB-2 class receptor binding [TAS]integrin binding [IPI]protein binding [IPI]structural constituent of cytoskeleton [NAS]

Gene Ontology Cellular Component