EDF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NR1H3
Gene Ontology Biological Process
- apoptotic cell clearance [IMP]
- cellular response to lipopolysaccharide [IDA]
- cholesterol homeostasis [ISS]
- gene expression [TAS]
- intracellular receptor signaling pathway [TAS]
- lipid homeostasis [ISS]
- negative regulation of cholesterol storage [IMP]
- negative regulation of inflammatory response [ISS]
- negative regulation of interferon-gamma-mediated signaling pathway [NAS]
- negative regulation of lipid transport [IMP]
- negative regulation of macrophage activation [ISS]
- negative regulation of macrophage derived foam cell differentiation [IC]
- negative regulation of pancreatic juice secretion [ISS]
- negative regulation of pinocytosis [IMP]
- negative regulation of secretion of lysosomal enzymes [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol efflux [IDA, IMP]
- positive regulation of cholesterol homeostasis [IDA]
- positive regulation of cholesterol transport [IDA]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of lipoprotein lipase activity [IMP]
- positive regulation of receptor biosynthetic process [IDA]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of triglyceride biosynthetic process [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of circadian rhythm [TAS]
- response to progesterone [IDA]
- sterol homeostasis [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
- triglyceride homeostasis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
Multiprotein bridging factor (MBF-1) is a cofactor that was first described for its capacity to modulate the activity of fushi tarazu factor 1, a nuclear receptor originally implicated in Drosophila development. Recently, it has been shown that human MBF-1 stimulates the transcriptional activity of steroidogenic factor 1, a human homolog of fushi tarazu factor 1, which is implicated in steroidogenesis. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EDF1 NR1H3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID