CRP
Gene Ontology Biological Process
- acute-phase response [TAS]
- defense response to Gram-positive bacterium [TAS]
- inflammatory response [TAS]
- negative regulation of lipid storage [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of vasodilation [IDA, IMP]
- opsonization [TAS]
- positive regulation of gene expression [IDA]
- positive regulation of superoxide anion generation [IDA]
- regulation of interleukin-8 secretion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
C1QA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11.
C-reactive protein (CRP) is a major acute phase protein whose functions are not totally clear. In this study, we examined the interaction of CRP with factor H (FH), a key regulator of the alternative pathway (AP) of complement. Using the surface plasmon resonance technique and a panel of recombinantly expressed FH constructs, we observed that CRP binds to two closely ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID