BAIT
CRP
PTX1, RP11-419N10.4
C-reactive protein, pentraxin-related
GO Process (10)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- acute-phase response [TAS]
- defense response to Gram-positive bacterium [TAS]
- inflammatory response [TAS]
- negative regulation of lipid storage [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of vasodilation [IDA, IMP]
- opsonization [TAS]
- positive regulation of gene expression [IDA]
- positive regulation of superoxide anion generation [IDA]
- regulation of interleukin-8 secretion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
C1QA
complement component 1, q subcomponent, A chain
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Regulation of complement activation by C-reactive protein: targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11.
C-reactive protein (CRP) is a major acute phase protein whose functions are not totally clear. In this study, we examined the interaction of CRP with factor H (FH), a key regulator of the alternative pathway (AP) of complement. Using the surface plasmon resonance technique and a panel of recombinantly expressed FH constructs, we observed that CRP binds to two closely ... [more]
J. Immunol. Oct. 01, 1999; 163(7);3957-62 [Pubmed: 10490997]
Throughput
- Low Throughput
Curated By
- BioGRID