NCAM1
Gene Ontology Biological Process
- aging [IDA]
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [TAS]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [ISO]
- cellular response to inorganic substance [IEP]
- cellular response to molecule of bacterial origin [IEP]
- homotypic cell-cell adhesion [ISO]
- learning or memory [IDA, IMP]
- multicellular organismal response to stress [IDA]
- negative regulation of cell death [IMP]
- neuron development [IDA]
- neuron projection development [ISO]
- organ regeneration [IEP]
- peripheral nervous system axon regeneration [IEP]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- regulation of exocyst assembly [ISO]
- regulation of sensory perception of pain [IMP]
- response to cocaine [IDA]
- response to fluoxetine [IDA]
- response to inorganic substance [IEP]
- response to lead ion [IDA]
- thalamus development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPP2CA
Gene Ontology Biological Process
- cardiac ventricle development [IEP]
- cellular response to calcium ion [IEP]
- cellular response to cytokine stimulus [IEP]
- cellular response to ethanol [IEP]
- cellular response to follicle-stimulating hormone stimulus [IEP]
- cellular response to glucose stimulus [IEP, IMP]
- cellular response to insulin stimulus [IEP]
- cellular response to steroid hormone stimulus [IEP]
- heart development [IEP]
- mesoderm development [ISO]
- negative regulation of calcium ion transmembrane transporter activity [IMP]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of transcription factor import into nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein phosphatase type 2A activity [IMP]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [IDA]
- protein heterotrimerization [IMP]
- regulation of protein autophosphorylation [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein phosphorylation [IMP]
- regulation of receptor activity [IMP]
Gene Ontology Molecular Function- GABA receptor binding [ISO]
- enzyme binding [IPI]
- ion channel binding [IPI]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IMP]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISS]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein phosphatase 2A binding [IDA, IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, IMP, TAS]
- tau protein binding [IPI]
- GABA receptor binding [ISO]
- enzyme binding [IPI]
- ion channel binding [IPI]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein dimerization activity [IMP]
- protein domain specific binding [IDA]
- protein heterodimerization activity [ISS]
- protein kinase B binding [IPI]
- protein kinase binding [IDA]
- protein phosphatase 2A binding [IDA, IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, IMP, TAS]
- tau protein binding [IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A.
The neural cell adhesion molecule (NCAM) is implicated in important functions during development and maintenance of the nervous system. Two of the three major isoforms, NCAM 140 and NCAM 180, are transmembrane glycoproteins with large cytoplasmic domains of different length. The purpose of this study was to identify novel intracellular binding partners of NCAM 140 and NCAM 180. We expressed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCAM1 PPP2CA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID