NCAM1
Gene Ontology Biological Process
- aging [IDA]
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [TAS]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [ISO]
- cellular response to inorganic substance [IEP]
- cellular response to molecule of bacterial origin [IEP]
- homotypic cell-cell adhesion [ISO]
- learning or memory [IDA, IMP]
- multicellular organismal response to stress [IDA]
- negative regulation of cell death [IMP]
- neuron development [IDA]
- neuron projection development [ISO]
- organ regeneration [IEP]
- peripheral nervous system axon regeneration [IEP]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- regulation of exocyst assembly [ISO]
- regulation of sensory perception of pain [IMP]
- response to cocaine [IDA]
- response to fluoxetine [IDA]
- response to inorganic substance [IEP]
- response to lead ion [IDA]
- thalamus development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ROCK1
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- actin cytoskeleton organization [ISO]
- apical constriction [ISO]
- bleb assembly [ISO]
- cytoskeleton organization [IMP]
- leukocyte cell-cell adhesion [ISO]
- leukocyte migration [ISO]
- leukocyte tethering or rolling [ISO]
- membrane to membrane docking [ISO]
- myoblast migration [ISO, ISS]
- negative regulation of angiogenesis [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of focal adhesion assembly [ISO, ISS]
- regulation of actin filament-based process [ISO]
- regulation of keratinocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoskeleton [ISO, ISS]
- lamellipodium [ISO, ISS]
- plasma membrane [ISO, ISS]
- ruffle [ISO, ISS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A.
The neural cell adhesion molecule (NCAM) is implicated in important functions during development and maintenance of the nervous system. Two of the three major isoforms, NCAM 140 and NCAM 180, are transmembrane glycoproteins with large cytoplasmic domains of different length. The purpose of this study was to identify novel intracellular binding partners of NCAM 140 and NCAM 180. We expressed ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID