NCAM1
Gene Ontology Biological Process
- aging [ISO]
- cell surface receptor signaling pathway [IDA]
- homotypic cell-cell adhesion [IMP]
- learning or memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of cell death [ISO]
- neuron development [ISO]
- neuron projection development [IGI]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cardiac muscle cell proliferation [ISO]
- regulation of exocyst assembly [IMP]
- regulation of sensory perception of pain [ISO]
- response to cocaine [ISO]
- response to fluoxetine [ISO]
- response to lead ion [ISO]
- thalamus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLCG1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A.
The neural cell adhesion molecule (NCAM) is implicated in important functions during development and maintenance of the nervous system. Two of the three major isoforms, NCAM 140 and NCAM 180, are transmembrane glycoproteins with large cytoplasmic domains of different length. The purpose of this study was to identify novel intracellular binding partners of NCAM 140 and NCAM 180. We expressed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCAM1 PLCG1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.806 | BioGRID | 2672292 |
Curated By
- BioGRID