PDIA3
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [IBA, TAS]
- protein import into nucleus [TAS]
- protein retention in ER lumen [TAS]
- proteolysis [TAS]
- response to endoplasmic reticulum stress [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC2A1
Gene Ontology Biological Process
- L-ascorbic acid metabolic process [TAS]
- carbohydrate metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glucose transport [IDA, TAS]
- hexose transport [TAS]
- protein complex assembly [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The thiol-dependent reductase ERp57 interacts specifically with N-glycosylated integral membrane proteins.
The lumen of the endoplasmic reticulum contains a number of distinct molecular chaperones and folding factors, which modulate the folding and assembly of newly synthesized proteins and protein complexes. A subset of these luminal components are specific for glycoproteins, and, like calnexin and calreticulin, the thiol-dependent reductase ERp57 has been shown to interact specifically with soluble secretory proteins bearing N-linked ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID