BAIT
ZC3H18
NHN1
zinc finger CCCH-type containing 18
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DSP
DCWHKTA, DP, DPI, DPII
desmoplakin
GO Process (12)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- apoptotic process [TAS]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- desmosome organization [ISS]
- epidermis development [TAS]
- intermediate filament organization [ISS]
- keratinocyte differentiation [IDA]
- peptide cross-linking [IDA]
- protein localization to adherens junction [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- ventricular cardiac muscle cell action potential [IMP]
- ventricular compact myocardium morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.
Nuclear RNA metabolism is influenced by protein complexes connecting to both RNA-productive and -destructive pathways. The ZC3H18 protein binds the cap-binding complex (CBC), universally present on capped RNAs, while also associating with the nuclear exosome targeting (NEXT) complex, linking to RNA decay. To dissect ZC3H18 function, we conducted interaction screening and mutagenesis of the protein, which revealed a phosphorylation-dependent isoform. Surprisingly, the modified region of ... [more]
Cell Rep Dec. 02, 2017; 22(1);44-58 [Pubmed: 29298432]
Throughput
- High Throughput
Curated By
- BioGRID