ITSN1
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- synaptic vesicle endocytosis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VLDLR
Gene Ontology Biological Process
- glycoprotein transport [IDA]
- memory [TAS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nervous system development [TAS]
- positive regulation of dendrite development [ISS]
- receptor-mediated endocytosis [IDA]
- reelin-mediated signaling pathway [ISS]
- signal transduction [TAS]
- very-low-density lipoprotein particle clearance [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [IDA, ISS]
- calcium-dependent protein binding [IPI]
- glycoprotein binding [IPI]
- glycoprotein transporter activity [IDA]
- low-density lipoprotein receptor activity [TAS]
- protein binding [IPI]
- reelin receptor activity [ISS]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor activity [IDA]
- apolipoprotein binding [IDA, ISS]
- calcium-dependent protein binding [IPI]
- glycoprotein binding [IPI]
- glycoprotein transporter activity [IDA]
- low-density lipoprotein receptor activity [TAS]
- protein binding [IPI]
- reelin receptor activity [ISS]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.
Brain development and function depend on the directed and coordinated migration of neurons from proliferative zones to their final position. The secreted glycoprotein Reelin is an important factor directing neuronal migration. Loss of Reelin function results in the severe developmental disorder lissencephaly and is associated with neurological diseases in humans. Reelin signals via the lipoprotein receptors very low density lipoprotein ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VLDLR ITSN1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID