CRHR1
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- cellular response to corticotropin-releasing hormone stimulus [IDA]
- corticotropin secretion [ISS]
- female pregnancy [NAS]
- immune response [TAS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- parturition [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IMP]
- regulation of corticosterone secretion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS, TAS]
- axon guidance [TAS]
- dendritic spine morphogenesis [ISS]
- establishment of protein localization [IDA]
- learning [TAS]
- negative regulation of receptor internalization [ISS]
- nervous system development [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of synaptic transmission [ISS]
- protein complex assembly [IDA]
- protein localization to synapse [IDA]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
- synaptic vesicle maturation [ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
- D1 dopamine receptor binding [ISS]
- P2Y1 nucleotide receptor binding [ISS]
- PDZ domain binding [ISS]
- acetylcholine receptor binding [ISS]
- beta-1 adrenergic receptor binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [ISS]
- protein phosphatase binding [ISS]
- scaffold protein binding [ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISS]
- cell junction [ISS]
- cortical cytoskeleton [IDA]
- cytoplasm [ISS]
- dendrite cytoplasm [ISS]
- dendritic spine [ISS]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [ISS]
- excitatory synapse [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [ISS]
- ionotropic glutamate receptor complex [ISS]
- juxtaparanode region of axon [ISS]
- neuron projection terminus [ISS]
- neuron spine [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS, TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IDA]
- synapse [IDA]
- synaptic vesicle [ISS]
- voltage-gated potassium channel complex [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PSD-95 regulates CRFR1 localization, trafficking and ?-arrestin2 recruitment.
Corticotropin-releasing factor (CRF) is a neuropeptide commonly associated with the hypothalamic-pituitary adrenal axis stress response. Upon release, CRF activates two G protein-coupled receptors (GPCRs): CRF receptor 1 (CRFR1) and CRF receptor 2 (CRFR2). Although both receptors contribute to mood regulation, CRFR1 antagonists have demonstrated anxiolytic and antidepressant-like properties that may be exploited in the generation of new pharmacological interventions for ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLG4 CRHR1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID