BAIT
AXL
ARK, JTK11, Tyro7, UFO
AXL receptor tyrosine kinase
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- cell maturation [IEP]
- cellular response to interferon-alpha [IDA]
- cellular response to lipopolysaccharide [IDA]
- dendritic cell differentiation [IEP]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- peptidyl-tyrosine phosphorylation [TAS]
- phagocytosis [IDA]
- positive regulation of cytokine-mediated signaling pathway [IDA]
- positive regulation of natural killer cell differentiation [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPLP1
LP1, P1, RPP1
ribosomal protein, large, P1
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID