ATP7A
Gene Ontology Biological Process
- T-helper cell differentiation [ISS]
- blood vessel development [ISS]
- blood vessel remodeling [ISS]
- cartilage development [ISS]
- catecholamine metabolic process [ISS]
- cellular copper ion homeostasis [IMP]
- central nervous system neuron development [ISS]
- cerebellar Purkinje cell differentiation [ISS]
- collagen fibril organization [ISS]
- copper ion export [ISS]
- copper ion import [ISS]
- copper ion transport [IMP]
- detoxification of copper ion [ISS]
- dopamine metabolic process [ISS]
- elastic fiber assembly [ISS]
- elastin biosynthetic process [ISS]
- epinephrine metabolic process [ISS]
- extracellular matrix organization [ISS]
- hair follicle morphogenesis [ISS]
- ion transmembrane transport [TAS]
- locomotory behavior [ISS]
- lung alveolus development [ISS]
- mitochondrion organization [ISS]
- negative regulation of metalloenzyme activity [ISS]
- neuron projection morphogenesis [ISS]
- norepinephrine metabolic process [ISS]
- peptidyl-lysine modification [ISS]
- pigmentation [ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of oxidoreductase activity [IDA]
- pyramidal neuron development [ISS]
- regulation of oxidative phosphorylation [ISS]
- removal of superoxide radicals [ISS]
- serotonin metabolic process [ISS]
- skin development [ISS]
- transmembrane transport [TAS]
- tryptophan metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ATOX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.
Wilson disease (WD) and Menkes disease (MNK) are inherited disorders of copper metabolism. The genes that mutate to give rise to these disorders encode highly homologous copper transporting ATPases. We use yeast and mammalian two-hybrid systems, along with an in vitro assay to demonstrate a specific, copper-dependent interaction between the six metal-binding domains of the WD and MNK ATPases and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATP7A ATOX1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| ATOX1 ATP7A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID