LEPR
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- angiogenesis [IMP]
- cellular response to organic substance [IEP]
- cholesterol metabolic process [ISO]
- eating behavior [IMP]
- female pregnancy [IEP]
- generation of precursor metabolites and energy [NAS]
- leptin-mediated signaling pathway [IDA]
- negative regulation of gluconeogenesis [ISO]
- negative regulation of hydrolase activity [ISO]
- ovulation from ovarian follicle [IEP]
- positive regulation of MAPK cascade [IDA]
- response to estrogen [IEP]
- response to hypoxia [IEP]
- response to leptin [IEP]
- response to nicotine [IEP]
- response to nutrient [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOD
Gene Ontology Biological Process
- aging [IEP]
- brain development [IEP]
- glucose metabolic process [ISO, ISS]
- lipid metabolic process [ISO, ISS]
- negative regulation of T cell migration [ISO, ISS]
- negative regulation of cytokine production involved in inflammatory response [ISO, ISS]
- negative regulation of focal adhesion assembly [ISO, ISS]
- negative regulation of lipoprotein lipid oxidation [ISO, ISS]
- negative regulation of monocyte chemotactic protein-1 production [ISO, ISS]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO, ISS]
- negative regulation of protein import into nucleus [ISO, ISS]
- negative regulation of smooth muscle cell proliferation [ISO, ISS]
- negative regulation of smooth muscle cell-matrix adhesion [ISO, ISS]
- peripheral nervous system axon regeneration [IEP]
- response to axon injury [IEP]
- response to drug [IEP]
- response to reactive oxygen species [ISO, ISS]
- tissue regeneration [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Apolipoprotein D interacts with the long-form leptin receptor: a hypothalamic function in the control of energy homeostasis.
... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APOD LEPR | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| LEPR APOD | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID