BAIT
GRB10
GRB-IR, Grb-10, IRBP, MEG1, RSS
growth factor receptor-bound protein 10
GO Process (8)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISS, TAS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of glucose import [ISS]
- negative regulation of glycogen biosynthetic process [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- positive regulation of phosphorylation [ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- response to insulin [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CDH3
CDHP, HJMD, PCAD
cadherin 3, type 1, P-cadherin (placental)
GO Process (17)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
- adherens junction organization [TAS]
- canonical Wnt signaling pathway [IMP]
- cell adhesion [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- hair cycle process [IMP]
- keratinization [IMP]
- negative regulation of catagen [IMP]
- negative regulation of transforming growth factor beta2 production [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of insulin-like growth factor receptor signaling pathway [IMP]
- positive regulation of keratinocyte proliferation [IMP]
- positive regulation of melanin biosynthetic process [IMP]
- positive regulation of melanosome transport [IMP]
- positive regulation of monophenol monooxygenase activity [IMP]
- regulation of hair cycle by canonical Wnt signaling pathway [IMP]
- retina homeostasis [IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID