An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.

Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T

Cadherin adhesion molecules are believed to be important for synaptic plasticity. beta-Catenin, which links cadherins and the actin cytoskeleton, is a modulator of cadherin adhesion and regulates synaptic structure and function. Here we show that beta-catenin interacts with a novel GTPase-activating protein, named RICS, that acts on Cdc42 and Rac1. The RICS-beta-catenin complex was found to be associated with N-cadherin, ... [more]

J. Biol. Chem. Mar. 14, 2003; 278(11);9920-7 [Pubmed: 12531901]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

CAMK2A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTPase activating protein binding [ISO]calmodulin binding [ISO]calmodulin-dependent protein kinase activity [ISO]glutamate receptor binding [IPI]kinase activity [ISO]protein binding [IPI]protein homodimerization activity [ISO]protein serine/threonine kinase activity [IDA, IMP]

Gene Ontology Cellular Component

ARHGAP32