FKBP4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IRF4
Gene Ontology Biological Process
- T cell activation [NAS]
- T-helper 17 cell lineage commitment [ISS]
- cytokine-mediated signaling pathway [TAS]
- defense response to protozoan [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of interleukin-10 biosynthetic process [IDA]
- positive regulation of interleukin-13 biosynthetic process [IDA]
- positive regulation of interleukin-2 biosynthetic process [IDA]
- positive regulation of interleukin-4 biosynthetic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of T-helper cell differentiation [NAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription factor binding [NAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription factor binding [NAS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.
Interferon regulatory factor-4 (IRF-4) plays an important role in immunoregulatory gene expression in B and T lymphocytes and is also highly expressed in human T cell leukemia virus type 1 infected cells. In this study, we characterize a novel interaction between IRF-4 and the FK506-binding protein 52 (FKBP52), a 59 kDa member of the immunophilin family with peptidyl-prolyl isomerase activity ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID