BAIT
RDX
AA516625
radixin
GO Process (5)
GO Function (3)
GO Component (17)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- apical part of cell [IDA]
- cell periphery [ISO]
- cell tip [ISO]
- cell-cell adherens junction [ISO]
- cleavage furrow [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA]
- microvillus [IDA, ISO]
- midbody [ISO]
- myelin sheath [IDA]
- plasma membrane [ISO]
- ruffle [IDA]
- stereocilium [IDA]
Mus musculus
PREY
SLC9A3R2
E3KARP, NHE3RF2, NHERF-2, NHERF2, OCTS2, SIP-1, SIP1, TKA-1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
GO Process (1)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF).
Radixin is a member of the ERM proteins, which cross-link plasma membranes and actin filaments. The N-terminal FERM domains of ERM proteins interact with Na(+)/H(+)-exchanger regulatory factors (NHERFs), which are PDZ-containing adaptor proteins, to modulate the ion-channel activity. Here, crystals of complexes between the radixin FERM domain and the C-terminal regions of NHERF and NHERF2 have been obtained. The crystals ... [more]
Acta Crystallogr. D Biol. Crystallogr. Jan. 01, 2003; 59(0);177-9 [Pubmed: 12499563]
Throughput
- Low Throughput
Curated By
- BioGRID