BAIT
MAP2K3
MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
mitogen-activated protein kinase kinase 3
GO Process (18)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- innate immune response [TAS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SUPT5H
SPT5, SPT5H, Tat-CT1
suppressor of Ty 5 homolog (S. cerevisiae)
GO Process (16)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- DNA-templated transcription, elongation [IDA]
- cell cycle [NAS]
- chromatin remodeling [NAS]
- gene expression [TAS]
- negative regulation of DNA-templated transcription, elongation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of DNA-templated transcription, elongation [IDA]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of viral transcription [TAS]
- response to organic substance [TAS]
- single stranded viral RNA replication via double stranded DNA intermediate [NAS]
- transcription elongation from RNA polymerase II promoter [IDA, TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- DSIF complex [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID