BAIT
KRT8
CARD2, CK-8, CK8, CYK8, K2C8, K8, KO
keratin 8
GO Process (0)
GO Function (2)
GO Component (5)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLAT
T-PA, TPA
plasminogen activator, tissue
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18.
Cytokeratin 8 (CK8) is an intermediate filament protein that penetrates to the external surfaces of breast cancer cells and is released from cells in the form of soluble heteropolymers. CK8 binds plasminogen and tissue-type plasminogen activator (t-PA) and accelerates plasminogen activation on cancer cell surfaces. The plasminogen-binding site is located at the C-terminus of CK8. In this study, we prepared ... [more]
J. Protein Chem. Nov. 01, 1998; 17(8);845-54 [Pubmed: 9988531]
Throughput
- Low Throughput
Curated By
- BioGRID