BAIT
ID2
AI255428, C78922, Idb2, bHLHb26
inhibitor of DNA binding 2
GO Process (49)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- Peyer's patch development [IGI]
- adipose tissue development [IMP]
- bundle of His development [IMP]
- cell development [IGI]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular senescence [IMP]
- circadian regulation of gene expression [IMP]
- embryonic digestive tract morphogenesis [IDA]
- entrainment of circadian clock [IMP]
- entrainment of circadian clock by photoperiod [IMP]
- enucleate erythrocyte differentiation [IGI]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- heart development [IGI]
- leukocyte differentiation [IMP]
- locomotor rhythm [IMP]
- lymph node development [TAS]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell proliferation [IMP]
- membranous septum morphogenesis [IMP]
- metanephros development [IMP]
- natural killer cell differentiation [IGI, IMP]
- negative regulation of B cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- neuron fate commitment [IMP]
- olfactory bulb development [IMP]
- oligodendrocyte development [IMP]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of circadian rhythm [IMP]
- regulation of lipid metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ID2
AI255428, C78922, Idb2, bHLHb26
inhibitor of DNA binding 2
GO Process (49)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- Peyer's patch development [IGI]
- adipose tissue development [IMP]
- bundle of His development [IMP]
- cell development [IGI]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular senescence [IMP]
- circadian regulation of gene expression [IMP]
- embryonic digestive tract morphogenesis [IDA]
- entrainment of circadian clock [IMP]
- entrainment of circadian clock by photoperiod [IMP]
- enucleate erythrocyte differentiation [IGI]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- heart development [IGI]
- leukocyte differentiation [IMP]
- locomotor rhythm [IMP]
- lymph node development [TAS]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell proliferation [IMP]
- membranous septum morphogenesis [IMP]
- metanephros development [IMP]
- natural killer cell differentiation [IGI, IMP]
- negative regulation of B cell differentiation [IMP]
- negative regulation of DNA binding [IDA]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of neural precursor cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- neuron fate commitment [IMP]
- olfactory bulb development [IMP]
- oligodendrocyte development [IMP]
- positive regulation of astrocyte differentiation [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of cell cycle [ISO]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of circadian rhythm [IMP]
- regulation of lipid metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function.
Id proteins are negative regulators of basic helix-loop-helix (bHLH) transcription factors. In this study, we compared the expression of Id2 mRNA in proliferating (fetal) and nonproliferating (adult) alveolar epithelial cells (AECs). The expression of Id2 was higher in adult AECs than in the corresponding fetal cells, suggesting that Id2 might play a functional role in developmental regulation of lung epithelial ... [more]
Biochem. Biophys. Res. Commun. Jul. 14, 2000; 273(3);1042-7 [Pubmed: 10891368]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID