BAIT
RAC1
ras-related C3 botulinum toxin substrate 1
GO Process (52)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IDA, ISO]
- Rac protein signal transduction [TAS]
- Wnt signaling pathway, planar cell polarity pathway [ISO]
- actin cytoskeleton organization [IDA, ISO]
- actin filament organization [IMP]
- actin filament polymerization [ISO]
- anatomical structure arrangement [ISO]
- auditory receptor cell morphogenesis [ISO]
- axon guidance [ISO]
- bone resorption [IDA]
- cell adhesion [ISO]
- cell migration [ISO]
- cell motility [ISO, ISS]
- cell proliferation [IMP]
- cell-cell junction organization [ISO]
- cellular component movement [IMP]
- cerebral cortex radially oriented cell migration [ISO]
- chemotaxis [IMP]
- cochlea morphogenesis [ISO]
- cytoskeleton organization [ISO]
- dendrite development [ISO]
- dendrite morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- embryonic olfactory bulb interneuron precursor migration [ISO]
- endocytosis [ISO]
- engulfment of apoptotic cell [ISO]
- epithelial cell morphogenesis [ISO]
- hyperosmotic response [ISO]
- lamellipodium assembly [ISO]
- localization within membrane [ISO]
- mast cell chemotaxis [IMP]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [ISO]
- positive regulation of DNA replication [IMP]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [ISO]
- regulation of cell migration [ISO, ISS]
- regulation of respiratory burst [ISO]
- ruffle assembly [ISO]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [IMP]
- small GTPase mediated signal transduction [ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- actin filament [ISO]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [ISO]
- focal adhesion [ISO]
- lamellipodium [ISO]
- membrane [IDA, ISO]
- phagocytic cup [ISO]
- ruffle membrane [ISO]
- trans-Golgi network [ISO]
Rattus norvegicus
PREY
TUBB2B
RGD1309427, Tubb2
tubulin, beta 2B class IIb
GO Process (1)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
- microtubule [ISO]
- nucleus [ISO]
Rattus norvegicus
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The Ras-related GTPase Rac1 binds tubulin.
The Ras-related Rho family are involved in controlling actin-based changes in cell morphology. Microinjection of Rac1, RhoA, and Cdc42Hs into Swiss 3T3 cells induces pinocytosis and membrane ruffling, stress fiber formation, and filopodia formation, respectively. To identify target proteins involved in these signaling pathways cell extracts immobilized on nitrocellulose have been probed with [gamma-32P]GTP-labeled Rac1, RhoA, and Cdc42Hs. We have ... [more]
J. Biol. Chem. Feb. 16, 1996; 271(7);3756-62 [Pubmed: 8631991]
Throughput
- Low Throughput
Curated By
- BioGRID