BAIT
RPS6KA3
CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2, RP11-393H10.3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
GO Process (28)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- axon guidance [TAS]
- central nervous system development [TAS]
- innate immune response [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of cell differentiation [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of DNA-templated transcription in response to stress [TAS]
- regulation of translation in response to stress [TAS]
- response to lipopolysaccharide [ISS]
- signal transduction [TAS]
- skeletal system development [TAS]
- stress-activated MAPK cascade [TAS]
- synaptic transmission [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
PREY
HMGA1
HMG-R, HMGA1A, HMGIY, RP11-513I15.2
high mobility group AT-hook 1
GO Process (16)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA unwinding involved in DNA replication [NAS]
- base-excision repair [IDA]
- establishment of integrated proviral latency [TAS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chromatin silencing [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome disassembly [TAS]
- oncogene-induced cell senescence [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [TAS]
- regulation of transcription, DNA-templated [TAS]
- response to virus [IEP]
- senescence-associated heterochromatin focus assembly [IDA]
- viral process [TAS]
Gene Ontology Molecular Function- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
- 5'-deoxyribose-5-phosphate lyase activity [IDA]
- AT DNA binding [TAS]
- DNA binding [TAS]
- DNA-(apurinic or apyrimidinic site) lyase activity [IDA]
- enzyme binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- peroxisome proliferator activated receptor binding [IDA]
- protein binding [IPI]
- retinoic acid receptor binding [IDA]
- retinoid X receptor binding [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID