BAIT
AUP1
ancient ubiquitous protein 1
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGA1
CD49a, VLA1
integrin, alpha 1
GO Process (8)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-matrix adhesion [IMP]
- extracellular matrix organization [TAS]
- muscle contraction [TAS]
- negative regulation of cell proliferation [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.
Modification of the cytoplasmic tails of the integrin alpha(IIb)beta(3) plays an important role in the signal transduction in platelets. We searched for proteins that bind to the alpha(IIb) cytoplasmic tail using the yeast two-hybrid assay with a cDNA library of the megakaryocyte-derived cell line and identified a protein, ancient ubiquitous protein 1 (Aup1), that is ubiquitously expressed in human cells. ... [more]
J. Biol. Chem. Aug. 09, 2002; 277(32);28934-41 [Pubmed: 12042322]
Throughput
- Low Throughput
Curated By
- BioGRID