BAIT
AUP1
ancient ubiquitous protein 1
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGA2
BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
GO Process (12)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell adhesion mediated by integrin [IMP]
- cell-matrix adhesion [IMP]
- cell-substrate adhesion [IMP]
- collagen-activated signaling pathway [IMP]
- extracellular matrix organization [TAS]
- integrin-mediated signaling pathway [IMP]
- mesodermal cell differentiation [IEP]
- organ morphogenesis [TAS]
- substrate-dependent cell migration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.
Modification of the cytoplasmic tails of the integrin alpha(IIb)beta(3) plays an important role in the signal transduction in platelets. We searched for proteins that bind to the alpha(IIb) cytoplasmic tail using the yeast two-hybrid assay with a cDNA library of the megakaryocyte-derived cell line and identified a protein, ancient ubiquitous protein 1 (Aup1), that is ubiquitously expressed in human cells. ... [more]
J. Biol. Chem. Aug. 09, 2002; 277(32);28934-41 [Pubmed: 12042322]
Throughput
- Low Throughput
Curated By
- BioGRID