BAIT
AUP1
ancient ubiquitous protein 1
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGA5
CD49e, FNRA, VLA5A
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
GO Process (13)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- angiogenesis [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell adhesion [TAS]
- cell-substrate adhesion [IMP]
- endodermal cell differentiation [IMP]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- leukocyte migration [TAS]
- negative regulation of anoikis [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- wound healing, spreading of epidermal cells [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.
Modification of the cytoplasmic tails of the integrin alpha(IIb)beta(3) plays an important role in the signal transduction in platelets. We searched for proteins that bind to the alpha(IIb) cytoplasmic tail using the yeast two-hybrid assay with a cDNA library of the megakaryocyte-derived cell line and identified a protein, ancient ubiquitous protein 1 (Aup1), that is ubiquitously expressed in human cells. ... [more]
J. Biol. Chem. Aug. 09, 2002; 277(32);28934-41 [Pubmed: 12042322]
Throughput
- Low Throughput
Curated By
- BioGRID